mOTS-400s
UTTA CAR-T
Mechanism of mOTS-400s
1. Islam, S., Lee, B., Jiang, F., Kim, E. K., Ahn, S. C., & Hwang, T. H. (2020).
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase. Cancers, 12(1), 228.
2. Islam, S., Hong, Y. M., Ornella, M., Ngabire, D., Jang, H., Cho, E., Kim, E. K., Hale, J., Kim, C. H., Ahn, S. C., Cho, M., & Hwang, T. H. (2020).
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Biomedicines, 8(10), 426
Mechanism of UTTA CAR-T
mOTS-400s 항암 바이러스 투여 후 종양 세포막 표면에
발현하는 UTTA (Universal Tumor Targeting Antigen)를 표적하는 CAR-T 세포치료제를 개발 중에 있습니다